image ares brain

The Project

This project presents an innovative approach towards a personalized treatment and therapy of glioblastoma (GBM), the most common malignant primitive brain tumor. With currently available therapies (surgery followed by chemo and radio therapy) the average life expectancy of the affected patients is only one year. Surgery alone is not able to completely eradicate the tumor due to the infiltrative nature of GBM. Additionally, the cancer cells can rapidly develop resistance to currently available therapies. Through the union of the scientific and technological skills of the partners, innovative experimental and computational techniques will be developed and integrate, in order to identify an effective system to face the disease.

Starting from the study of Glioblastoma cells (GSC) and with the support of an advanced integrated technology platform, innovative methods of analysis, evaluation and treatment will be implemented and subsequently compared with the currently systems used in the therapeutic field.

Smart Health specialization Area

Innovative Therapy

Start date
September, 2018

End date
March, 2021

Total project
€ 1.085.821,19

Total grant
€ 833.432,93

Results

At the end of the project a glioblastoma stem cell bank will be available for implementation; new 3D in vitro models (to study the invasiveness of GBM cells) will be created; the results of the effectiveness evaluation tests of the molecules identified as candidates capable of blocking GBM growth will be formalized.

Furthermore, the following outputs will be developed with the possibility of future commercial use:

  • an integrated technological platform (Ecosystem) to be used in the area of advanced health data services;
  • diagnostic kits for in vitro prediction of the therapy response

Target

The project aims are:

  1. the identification of new therapies capable of blocking the proliferative and infectious capacity of GBM tumor cells, possibly extending these therapies to low-grade gliomas, to find an effective cure even in the initial phase of the disease;
  2. the development of new assays able to predict patients' response to drugs, thus allowing a personalization of the therapy.
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Partners

eXact lab is an innovative SME that provides solutions, training and on-demand services in the High Performance Computing and Data market. We assist our clients in the research, governmental and private sectors in defining the best HPC solutions that fit clients specific HPC needs. Our specialties cover a wide range of approaches: from procuring mission-critical HPC systems, maximizing the effectiveness of existing systems at client premises to on demand Cloud HPC services trough our own C3HPC infrastructure.

Our C3HPC services are specifically tailored on the SME end-user offering them a high quality services which includes: preconfigured and fully operational hardware, compiled and optimized software, automatic management of complex computational workflows, ad hoc training and support remote visualization, data-management and data analysis services.

Via Beirut, 2 - 34151 Trieste - Italy

Within the Institute of Materials (Istituto Officina dei Materiali - IOM) of the Italian National Research Council (CNR), the research group is devoted to study the molecular mechanism of diseases' onset thanks to the use of computer simulations techniques (classical and ab initio molecular dynamics) as well as to design new drugs and repositioning of existing drugs via structure based drug design (virtual screening, docking).

Area Science Park, Basovizza, ss.14 Km 163,5 - 34149 – Trieste

The Dott. Dino Paladin Company operates in the following sectors:

  • Development and pilot production of biotechnology and nanotechnology products, particularly the development and patenting of drugs currently in production by another company; it has collaborated in research contract projects to develop more than 100 medical-diagnostic devices in-vitro labelled CE (CE IVD) in molecular biology.
  • Production, installation, repair and maintenance of medical instruments and software for:
    • molecular diagnosis;
    • devices for analysis and research;
    • tracing of workflow and samples in pathological anatomies;
    • development of products for the realisation and management of biobanks.

The company has solid research-and-development (R&D) experience in the field of human diagnostics, having collaborated with various universities in the study of tumour drug resistance, HLA typing, genetic diseases and viral typing to acquire and consolidate knowledge for avant-garde molecular biology techniques.

Area Science Park, Padriciano, 99 - 34149 – Trieste

The International School for Advanced Studies is a scientific center of excellence within the national and international academic scene. The three main research areas of SISSA are Physics, Neuroscience and Mathematics, and in these areas the School has drawn up over 150 collaboration agreements with the world’s leading schools and research institutes.

All the scientific work carried out by SISSA researchers is published in the most prestigious scientific journals, demonstrating that Technology and knowledge transfer is a crucial and strategic SISSA activity within the more general mission of creating innovation and guaranteeing valorization of research and talents.

As project partner the research group active in Neurobiology is investigating the molecular, cellular and integrative mechanisms at work in the nervous system.

Neurobiologists seek to explain the underlying processes that ultimately account for behavior and for its dysfunction at the level of molecules, cells, networks and integrated systems. To carry out such complex studies, a variety of experimental approaches and scientific disciplines are required, ranging from mathematics and physics to biology.

Via Bonomea 265 - 34136 Trieste - Italy

Higher education, research, technology transfer, interaction with the territory and internationalization: these are the areas of intervention of the University of Udine, which promotes cutting-edge skills translated into international scientific partnerships, publications, books and patents. This is the synthesis of multidisciplinary research activities developed in departments such as DAME - Department of Medical Area, established in 2017 with the aim of carrying out institutional research and teaching activities.

The Department activities consists of: organize study courses in the area of medical education, health professions, sports science and biotechnology; promote closely collaboration with the Integrated University Hospital of Udine ( ASUIUD); sustain among the several research groups the "Immunohistochemical and molecular techniques in the diagnostic pathological anatomy" group, which through its research activities aims to develop analysis protocols aimed at treating patients through personalized therapeutic approaches

Via Palladio 8 - 33100 Udine - Italy